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DNA ligase IV Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand: Invitrogen PA528903

Product Code. 13403027

3955.00 DKK / 100µL

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Description

Recommended positive controls: U87-MG, mouse brain, rat brain. Predicted reactivity: Mouse (82%), Rat (81%), Sheep (83%), Bovine (86%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

Specifications

Antigen	DNA ligase IV
Classification	Polyclonal
Conjugate	Unconjugated
Gene	LIG4
Gene Alias	5830471N16Rik; DNA joinase; DNA ligase (ATP) 4; DNA ligase 4; DNA ligase IV; DNA repair enzyme; Lig4; LIG4S; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase; tiny
Host Species	Rabbit
Purification Method	Antigen affinity chromatography
Regulatory Status	RUO
Gene ID (Entrez)	290907, 319583, 3981
Content And Storage	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form	Liquid

Applications	Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration	1 mg/mL
Formulation	0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.	P49917, Q8BTF7
Gene Symbols	LIG4
Immunogen	Recombinant fragment corresponding to a region within amino acids 558 and 823 of Human DNA ligase IV
Quantity	100 μL
Primary or Secondary	Primary
Target Species	Human, Mouse, Rat
Product Type	Antibody
Isotype	IgG

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DNA ligase IV Polyclonal Antibody, Invitrogen™ > 100 μL; Unconjugated

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DNA ligase IV Polyclonal Antibody, Invitrogen™

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