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  6. Calcineurin Mouse, Unlabeled, Clone: 29, BD

Calcineurin Mouse, Unlabeled, Clone: 29, BD

Artikelnummer. 15815369
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Mængde:
150 μg
50 μg
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Artikelnummer. Mængde
15815369 50 μg
15825369 150 μg
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Artikelnummer. 15815369 Leverandør BD Biosciences Leverandørnr. 610259

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Beskrivelse

Mouse Monoclonal Antibody

Calcineurin is a Ca2+/calmodulin-dependent protein phosphatase. The active enzyme is a heterodimer of a large calmodulin-binding catalytic subunit A (61kDa) and a smaller Ca2+ binding subunit B (19kDa). Regions corresponding to the calmodulin-binding site, an autoinhibitory domain, and a putative subunit B binding site have been identified within the large subunit A. The activity of calcineurin is sensitive to immunosuppressants such as cyclosporin A (CsA) and tacrolimus (FK506). The study of FK506-mediated inhibition of nitric oxide formation has revealed that nitric oxide synthase (NOS) is a calcineurin substrate. Calcineurin dephosphorylates NOS and enhances its catalytic activity. Therefore, Calcineurin is an essential mediator for efficient T cell antigen receptor (TCR)-mediated T cell activation.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Tekniske data

Antigen Calcineurin
Applikationer Western Blot
Klassifikation Monoclonal
Klon 29
Koncentration 250μg/mL
Konjugeret Unconjugated
Formulering Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Værtsarter Mouse
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Oprensningsmetode Affinity Purified
Mængde 50 μg
Regulatorisk status RUO
Forskningsdisciplin Cell Biology
Primær eller sekundær Primary
Målarter Chicken, Frog, Human, Mouse, Rat
Indhold og opbevaring Store undiluted at -20°C.
Isotype IgG2a
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For Research Use Only.

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