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Tocris Bioscience™ AMG 510
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Artikelnummer. 18769346
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50 mg
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18769346 50 mg
18717466 10 mg
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Artikelnummer. 18769346 Leverandør Tocris Bioscience™ Leverandørnr. 7713/50

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Beskrivelse

Potent and selective KRASG12C inhibitor

AMG 510 is a potent and selective covalent KRASG12C inhibitor (IC50 = 90 nM). Also a potent inhibitor of phospho-ERK (IC50 = 68 nM). In an in vivo model of non-small cell lung cancer, AMG 510 causes regression of tumors, an increase in T-cell recruitment and a pro-inflammatory tumor microenvironment. Synergises with MEK inhibitors and Carboplatin (Cat. No. 2626) and is orally bioavailable.
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Tekniske data

Kemisk navn eller materiale (1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
CAS 2252403-56-6
Mængde 50 mg
Mål Ras GTPase Inhibitors
Molekylær formel C30H30F2N6O3
Renhed 0.98
Produkttitel
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