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Almorexant, MedChemExpress

Artikelnummer. 16476877
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16476877 5 mg
16435136 100 mg
16414178 10 mg
16410527 50 mg
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Artikelnummer. 16476877 Leverandør Medchem Express Leverandørnr. HY10805

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Beskrivelse

MedChemExpress Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.

Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.

Tekniske data

Kemisk navn eller materiale Almorexant
CAS 871224-64-5
Farve White
Renhedsgrad noter Research
Molekylær formel C29H31F3N2O3
Mængde 5 mg
Synonym ACT 078573
Opløselighedsinformation DMSO : ≥ 46 mg/mL (89.75 mM)
SMIL CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O
Molekylvægt (g/mol) 512.56
Formel vægt 512.56
Procent renhed 99.01%
Grad Research
Fysisk form Solid
Til brug med (applikation) Neuroscience-Neuromodulation
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Research purposes only

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