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Tocris Bioscience™ AGI 5198
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Artikelnummer. 18796816
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5 mg
25 mg
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18796816 25 mg
18739466 5 mg
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Product Code. 18796816 Supplier Tocris Bioscience™ Supplier No. 7087/25

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Description

Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)

AGI 5198 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1; IC50 = 70 nM). Selective for mIDH1 over wild-type IDH1 and IDH2. Inhibits production of oncometabolite D-2 hydroxyglutarate. Attenuates growth of glioma cells containing mIDH1, but not wild-type IDH1, in vitro and in vivo. Also inhibits growth of fibrosarcoma and chondrosarcoma cells bearing mIDH1.
TRUSTED_SUSTAINABILITY

Specifications

Kemisk navn eller materiale N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1 H-Imidazole-1-acetamide
CAS 1355326-35-0
Mængde 25 mg
Mål Dehydrogenase Inhibitors
Molekylær formel C27H31FN4O2
Renhed 0.98
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