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Afatinib dimaleate, MedChemExpress

Artikelnummer. 16473748
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16473748 10 mg
16444816 100 mg
16410137 50 mg
16450966 200 mg
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Artikelnummer. 16473748 Leverandør Medchem Express Leverandørnr. HY10261A

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Beskrivelse

MedChemExpress Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.

Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.

Tekniske data

Kemisk navn eller materiale Afatinib dimaleate
CAS 850140-73-7
Farve White
Renhedsgrad noter Research
Molekylær formel C32H33ClFN5O11
Mængde 10 mg
Synonym BIBW 2992MA2
Opløselighedsinformation H2O : 50 mg/mL (69.63 mM; Need ultrasonic) ∣DMSO : ≥ 35 mg/mL (48.74 mM)
SMIL O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)/C=C/CN(C)C.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O
Molekylvægt (g/mol) 718.08
Formel vægt 718.08
Procent renhed 95.0%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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