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Tocris Bioscience™ ABX 464
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Artikelnummer. 18756436
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10 mg
50 mg
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Artikelnummer. Mængde
18756436 10 mg
18739836 50 mg
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Artikelnummer. 18756436 Leverandør Tocris Bioscience™ Leverandørnr. 6460/10

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Beskrivelse

HIV RNA splicing modulator

ABX 464 is an HIV RNA splicing modulator; it selectively enhances the splicing of HIV RNA in infected human PBMCs and inhibits viral replication, with no global effect on cellular splicing. ABX 464 inhibits replication of HIV strains harboring mutations associated with drug-resistance. ABX 464 binds the cap binding complex (CBC) and upregulates miR-124 expression in vitro and decreases expression of miR-124 target genes, MCP-1, CXCL-1, SERPIN-E1 in macrophages. It also decreases the number of Th17 cells, as well as IL-6 soluble receptor in CD4+ T cells. In HIV infected humanized mice, treatment with ABX 464 reduces viral load. Anti-inflammatory.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
CAS 1258453-75-6
Mængde 10 mg
Mål DNA, RNA and Protein Synthesis Compounds
Molekylær formel C16H10ClF3N2O
Renhed 0.98
Produkttitel
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