missing translation for 'onlineSavingsMsg'
Få mere at vide
  1. Home
  2. Products
  3. Proteinanalysereagenser
  4. Bioaktive små molekyler
  5. STEMCELL Technologies A769662

STEMCELL Technologies A769662

Artikelnummer. 17170142
Encompass_Preferred
Skift visning
Klik for at se tilgængelige muligheder
Mængde:
10 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Artikelnummer. Mængde
17170142 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Denne vare kan ikke returneres. Se returpolicy
Artikelnummer. 17170142 Leverandør STEMCELL Technologies Leverandørnr. 72922

Please to purchase this item. Need a web account? Register with us today!

Denne vare kan ikke returneres. Se returpolicy

Beskrivelse

AMPK activator

  • A769662 is a cell-permeable, direct activator of AMP-activated protein kinase (AMPK) with an EC50 of 116 nM (Goransson et al.) A 4.1-fold stimulation of AMPK is observed, via an allosteric mechanism, which potentially inhibits dephosphorylation on Thr172 (Goransson et al.; Sanders et al.) A769662 specifically activates β1 subunit–containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK
  • Activation of AMPK can inhibit the mTORC1 signaling pathway (Huang et al.) A769662 is also an inhibitor of Na(+)-K(+)-ATPase (Benziane et al.)
  • Inhibits reprogramming of mouse fibroblasts to induced pluripotent stem cells (Vazquez-Martin et al.)
  • Inhibits proliferation of mesenchymal stem cells (de Meester et al.)
  • Delays tumor onset in PTEN-deficient mice (Huang et al.)
  • Inhibits fatty acid synthesis in primary rat hepatocytes and lowers blood glucose in Sprague Dawley rats (Cool et al.)

Tekniske data

CAS 844499-71-4
Mængde 10 mg
Molekylær formel C20H12N2O3S
Renhed ≥98%
Produkttitel
Vælg et problem

Ved at klikke på Send, anerkender du, at du kan blive kontaktet af Fisher Scientific med hensyn til den feedback, du har givet i denne formular. Vi deler ikke dine oplysninger til andre formål. Alle angivne kontaktoplysninger skal også vedligeholdes i overensstemmelse med vores Privatlivspolitik.