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STEMCELL Technologies A 83-01

Artikelnummer. 17150012
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17150012 5 mg
17109971 50 mg
17160012 10 mg
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Artikelnummer. 17150012 Leverandør STEMCELL Technologies Leverandørnr. 72022

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Beskrivelse

Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7

  • A 83-01 is a potent inhibitor of activin receptor-like kinase (ALK) including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with IC50 = 12, 45, and 7.5 nM, respectively (Tojo et al.)
  • Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.)
  • In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.)
  • Inhibits mesoderm and endoderm specification (Zhang et al.)
  • Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.)

Tekniske data

CAS 909910-43-6
Mængde 5 mg
Molekylær formel C25H19N5S
Renhed ≥95%
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