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A 485, Tocris Bioscience™
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Histone Acetyltransferase Inhibitors

Brand:  Tocris Bioscience 6387/25

Encompass

Produktkode 15987930

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Beskrivelse

Beskrivelse

A 485 is a potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC50 values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively), which displays > 1000-fold selectivity over closely related HATs. A 485 suppresses proliferation in several hematological malignancies and AR+ prostate cancer cell lines in vitro, and also inhibits tumor growth in a castration-resistant prostate cancer xenograft model. A 485 is orally bioavailable.

To request the negative control for A 485, please fill out the A 486 request form on the SGC website.

Tekniske data

Tekniske data

1889279-16-6
(1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2′,4′-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5′-oxazolidine]-3′-acetamide
25 mg
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