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A-317491, MedChemExpress

Artikelnummer. 16479197
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Artikelnummer. 16479197 Leverandør Medchem Express Leverandørnr. HY15568

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MedChemExpress A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux.

A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux.

Tekniske data

Kemisk navn eller materiale A-317491
CAS 475205-49-3
Farve Pink
Renhedsgrad noter Research
Molekylær formel C33H27NO8
Mængde 5 mg
Opløselighedsinformation DMSO : ≥ 47 mg/mL (83.10 mM) ∣H2O : < 0.1 mg/mL (insoluble)
SMIL O=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[C@H]4CCCC5=C4C=CC=C5)=O)=C(C(O)=O)C=C1C(O)=O)O
Molekylvægt (g/mol) 565.57
Formel vægt 565.57
Procent renhed 98.25%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-programmed cell death
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Research purposes only

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