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Thiostrepton, Streptomyces laurentii, 90+%, Thermo Scientific™
Natural cyclic oligopeptide antibiotic
Brand: Thermo Scientific Alfa Aesar J62332.03
| Mængde | 1g |
|---|
Denne vare kan ikke returneres.
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Beskrivelse
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
ApplicationsThiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1. Thiostrepton has been used as a selectable marker for recombinant Streptomyces cultures.
Solubility
Soluble in DMSO or chloroform
Notes
Store at -20°C. Incompatible with oxidizing agents. Protect from heat.
Tekniske data
| Thiostrepton | |
| 1393-48-2 | |
| 1g | |
| MFCD00135828,MFCD00135828 | |
| Bryamycin; Thiactin | |
| NSFFHOGKXHRQEW-DVRIZHICNA-N | |
| 2-({2-[(11E)-37-(butan-2-yl)-18-(2,3-dihydroxybutan-2-yl)-11-ethylidene-59-hydroxy-8,60-bis(1-hydroxyethyl)-26,40,46-trimethyl-43-methylidene-6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,30,36,39,42,45,48,52,58,62,63,64-pentadecaazanonacyclo[23.23.9.2²⁹,³².1²,⁵.1¹²,¹⁵.1¹⁹,²².1³¹,³⁵.1⁵⁴,⁵⁷.0¹,⁵³]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazol-4-yl}formamido)-N-(1-carbamoyleth-1-en-1-yl)prop-2-enamide | |
| 122173112 | |
| ≥90% |
| Streptomyces laurentii | |
| White to Yellow | |
| C72H85N19O18S5 | |
| 14,9364 | |
| Soluble in DMSO or chloroform | |
| CCC(C)C1NC2C=CC3=C(C=C(N=C3C2O)C(=O)OC(C)C2NC(=O)C3=CSC(=N3)C(NC(=O)C3CSC(=N3)\C(NC(=O)C(NC(=O)C3=CSC(=N3)C3(CCC(=NC3C3=CSC2=N3)C2=NC(=CS2)C(=O)NC(=C)C(=O)NC(=C)C(N)=O)NC(=O)C(C)NC(=O)C(=C)NC(=O)C(C)NC1=O)C(C)O)=C/C)C(C)(O)C(C)O)C(C)O | |
| 1664.89 | |
| 1664.89 |
Produkttitel
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