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  5. Tocris Bioscience™ 6,8-Bis(benzylthio)octanoic acid

Tocris Bioscience™ 6,8-Bis(benzylthio)octanoic acid
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Artikelnummer. 18726148
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18726148 10 mg
18715578 50 mg
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Artikelnummer. 18726148 Leverandør Tocris Bioscience™ Leverandørnr. 5348/10

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Beskrivelse

PDH and KGDH inhibitor

6,8-Bis(benzylthio)octanoic acid is a pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) inhibitor. Disrupts tumor cell mitochondrial metabolism, and increases mitochondrial reactive oxygen species (ROS) production in H460 lung carcinoma cells. Has no effect on KGDH activity in normal bronchial epithelial cells. Induces cell death of multiple tumor cell lines selectively over normal cells in vitro. Inhibits tumor growth of H460 and BxPC-3 tumor cell xenografts in mice.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 6,8-Bis[(phenylmethyl)thio]octanoic acid
CAS 95809-78-2
Mængde 10 mg
Mål Dehydrogenase Inhibitors
Molekylær formel C22H28O2S2
Formel vægt 388.59
Renhed >99%
Produkttitel
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