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STEMCELL Technologies 4-Octyl Itaconate

Artikelnummer. 17160342
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17160342 50 mg
17170342 250 mg
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Artikelnummer. 17160342 Leverandør STEMCELL Technologies Leverandørnr. 74192

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Beskrivelse

Activates nuclear factor erythroid 2-related factor 2 (Nrf2) protein

  • 4-Octyl Itaconate is a cell-permeable derivative of itaconate, a metabolite produced during the Krebs cycle
  • It is a potent activator of nuclear factor erythroid 2-related factor 2 (Nrf2) via alkylation of the inhibitor of Nrf2 (Keap1), thereby promoting Nrf2-mediated transcriptional activation and downstream anti-oxidant and anti-inflammatory properties (Mills et al.; Tang et al.)
  • The itaconate pathway (IRG1-itaconate-SDH) plays a pivotal role in up-regulating tolerance and inhibiting the induction of trained immunity (Domínguez-Andrés et al.)
  • Counteracts the proinflammatory signals of succinate by inhibiting succinate dehydrogenase (SDH) and activating Nrf2 to limit inflammation in mouse and human macrophages (Lampropoulou et al.; Mills et al.)
  • Activates Nrf2 signaling in human macrophages, which has been shown to inhibit the production of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6 (Tang et al.)

Tekniske data

CAS 3133-16-2
Synonym 2-methylene-butanedioic acid; 4-octyl ester
Mængde 50 mg
Molekylær formel C13H22O4
Renhed ≥98%
Produkttitel
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