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4-Chloro-2-(methylthio)pyrimidine, 98%, Thermo Scientific Chemicals
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Quantity:
10 g
50 g
250 g
Description
It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.
Solubility
Not miscible or difficult to mix in water.
Notes
Moisture sensitive. Store away from oxidizing agents, bases, water/moisture, heat and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated.
It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.
Solubility
Not miscible or difficult to mix in water.
Notes
Moisture sensitive. Store away from oxidizing agents, bases, water/moisture, heat and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated.
Specifications
| Melting Point | ∼-2°C |
| Density | 1.38 |
| Boiling Point | 118°C to 120°C (9 mmHg) |
| Flash Point | >110°C (230°F) |
| Refractive Index | 1.6 00 |
| Quantity | 250 g |
| UN Number | UN1760 |
| Beilstein | 118042 |
| Sensitivity | Moisture sensitive; May form a precipitate |
| Solubility Information | Not miscible or difficult to mix in water. |
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RUO – Research Use Only
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