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Tocris Bioscience™ 2R,6R-Hydroxynorketamine hydrochloride

Artikelnummer. 18045082
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Mængde:
10 mg
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Artikelnummer. Mængde
18045082 10 mg
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Artikelnummer. 18045082 Leverandør Tocris Bioscience™ Leverandørnr. 6094/10

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Beskrivelse

Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects

2R,6R-Hydroxynorketamine hydrochloride is a ketamine metabolite. It enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices and decreases intracellular DL>D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.68 nM). 2R,6R-Hydroxynorketamine upregulates KCNQ2 channels in mouse ventral hippocampal glutamatergic neurons in vitro and in vivo. Exerts antidepressant effects in mice. Lacks ketamine-related side effects. 2S,6S-Enantiomer and Racemate also available.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
CAS 1430202-69-9
Mængde 10 mg
Mål AMPA Receptor Agonists
Molekylær formel C12H14ClNO2.HCl
Renhed 98%
Produkttitel
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