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Tocris Bioscience™ 2-Deoxy-D-glucose

Artikelnummer. 18013922
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Mængde:
50 mg
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18013922 50 mg
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Artikelnummer. 18013922 Leverandør Tocris Bioscience™ Leverandørnr. 4515/50

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Description

Non-metabolizable glucose analog; hexokinase substrate

2-Deoxy-D-glucose is a non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR). 2-Deoxy-D-glucose disrupts N-glycan expression on the surface of pancreatic adenocarcinoma cells. 2-Deoxy-D-glucose enhances chimeric antigen receptor T cell activity in different xenograft mouse models of pancreatic adenocarcinoma cells.
TRUSTED_SUSTAINABILITY

Specifications

Kemisk navn eller materiale 2-Deoxy-D-glucose
CAS 154-17-6
Mængde 50 mg
Molekylær formel C6H12O5
Formel vægt 164.16
Renhed >98%
Molekylvægt (g/mol) 164.16
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