CAS RN 2296729-00-3

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Sotorasib, MedChemExpress

MedChemExpress Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Sotorasib
Formel vægt	560.59
Opløselighedsinformation	DMSO : 50 mg/mL (89.19 mM; Need ultrasonic) ∣H2O : 33.33 mg/mL (59.46 mM; ultrasonic and adjust pH to 11 with NaOH)
Procent renhed	98.0%
Fysisk form	Powder
Farve	White
Grad	Research
Anbefalet opbevaring	-20°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Molekylvægt (g/mol)	560.59
CAS	2296729-00-3
Synonym	AMG-510
Holdbarhed	-20°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
SMIL	O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1
Renhedsgrad noter	Research
Molekylær formel	C₃₀H₃₀F₂N₆O₃
Til brug med (applikation)	Cancer-Kinase/protease

CAS RN 2296729-00-3

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