ZC3H12A, also known as MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. ZC3H12A has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to ...
Cat # 16350175
100 µL
Cat # 16813535
150 µL
Cat # 17288333
100 µL
Cat # 12859072
100 µg
Cat # 16093767
100 ug
Cat # 16340175
100 µL
Cat # 16823535
20 µL
Cat # 16175290
100 uL
Cat # 13279618
100 µL
Cat # 13282329
400 µL
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