This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
HCCS-4; Human cervical cancer suppressor gene 4 protein; Leucine zipper- and sterile alpha motif kinase ZAK; Leucine zipper- and sterile alpha motif-containing kinase; Mitogen-activated protein kinase kinase kinase 20; Mitogen-activated protein kinase kinase kinase MLT; mixed lineage kinase 7; mixed lineage kinase with a leucine zipper and a sterile alpha motif; Mixed lineage kinase-related kinase; mixed lineage kinase-related kinase MRK-beta; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; MLTK; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK; sterile-alpha motif and leucine zipper containing kinase AZK
Cat # 15663815
100 µL
Cat # 16177316
100 µg
Cat # 16062897
100 ug
Cat # 16137326
100 µg
Cat # 15985195
100 µg
Cat # 16120353
100 µg
Cat # 16117326
200 uL
Cat # 16012757
100 ug
Cat # 13483487
100 µL
Cat # 13491837
100 µL
Cat # 16197316
100 µg
Cat # 15644925
100 µL
Cat # 16130353
100 µg
Cat # 16187316
200 uL
Cat # 16823874
20 µL
Cat # 17238923
100 µL
Cat # 16107326
100 µg
Cat # 16813874
150 µL
Cat # 16547581
100 µL
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