The INK4a-ARF locus encodes two unrelated proteins both of which function in tumor suppression. p14ARF arrests the cell cycle in a p53-dependent manner. p14ARF binds to mdm2 and promotes the rapid degradation of mdm2 proteinrequired for mdm2 modification and concurrent p53 stabilization and accumulation. This interaction is mediated by the exon 1Beta-encoded N-terminal domain of p14ARF and a C-terminal region of mdm2. Deletion of the ARF-INK4a locus simultaneously impairs both the INK4a-cyclin D/cdk4-RB and the ARF-mdm2-p53 pathways.
Alternative reading frame; ARF; ARF CDK4I CDKN2 CMM2 INK4 INK4A MLM MTS-1 MTS1 P14 P14ARF P16 P16-INK4A P16INK4 P16INK4A P19 P19ARF TP16 CDK4 inhibitor p16-INK4 cell cycle negative regulator beta cyclin-dependent kinase 4 inhibitor A cyclin-dependent kinase inhibitor 2A melanoma p16 inhibits CDK4 multiple tumor suppressor 1; CDK4 inhibitor p16-INK4; CDK4I; cell cycle negative regulator beta; Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); MTS-1; Multiple tumor suppressor 1; p14ARF; p16-INK4; p16-INK4a; Tumor suppressor ARF
Cat # 13427047
500 µL
Cat # 16307594
100 µL
Cat # 11528930
100 µL
Cat # 11315023
500 µL
Cat # 11546363
1 mL
Cat # 11565353
100 µg
Cat # 16323095
100 µL
Cat # 16302545
100 µL
Cat # 11526013
100 µg
Cat # 11546083
100 µL
Cat # 11526872
500 µL
Cat # 17126283
100 µL
Cat # 16312545
100 µL
Cat # 11563773
100 µg
Cat # 11585343
100 µL
Searching for an antibody we don't offer? We make custom antibodies for specific targets, species and applications.
More than 18,000 custom antibodies created so far.
Talk To A Specialist NowIf an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.