Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintece of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
hSSB1; hSSB1 OBFC2B Sensor of ssDNA subunit B1 SOSS B1 SOSS complex subunit B1 SSB1; LP3587; Nucleic acid-binding protein 2; oligonucleotide/oligosaccharide-binding fold containing 2B; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; single strand DNA-binding protein 1; Single-stranded DNA-binding protein 1; SOSS complex subunit B1; SOSS-B1
Cat # 16823644
20 µL
Cat # 15998784
100 µL
Cat # 15692535
400 µL
Cat # 16677134
100 µL
Cat # 15915404
100 µL
Cat # 16813644
150 µL
Cat # 15748601
100 µL
Cat # 16163479
50 µg
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