Human NAIF1 is located on chromosome 9q34.11 and encodes 327 amino acids with a homeodomain-like region and two nuclear localization signals at its N-terminal region. NAIF1 is conserved across diverse species, including human, mouse, crab-eating macaque, dog, chicken and frog, and shares no obvious homology to any known genes or proteins. NAIF1 was predomitly localized in the nucleus. Overexpression of NAIF1 inhibited cell growth and induced apoptosis. Furthermore, NAIF1 transfection caused both decreases in mitochondrial membrane potential and caspase-3 activation. In summary, NAIF1 is a nuclear protein that induces apoptosis when overexpressed.
bA379C10.2 C9orf90 DKFZp762G199; Nuclear apoptosis-inducing factor 1
Cat # 16371625
100 µL
Cat # 16557771
100 µL
Cat # 15958634
100 µL
Cat # 17100844
100 µg
Cat # 15624175
100 µL
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