The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is ...
Cat # 16883264
20 µL
Cat # 13230829
400 µL
Cat # 13401377
100 µL
Cat # 16873264
150 µL
Cat # 15976814
100 µL
Cat # 15782524
25 ug
Cat # 10352603
100 µg
Cat # 13448694
100 ug
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