Component of the BRISC complex, a multiprotein complex that specifically cleaves ′Lys-63′-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating ′Lys-63′-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon ...
Cat # 16855205
150 µL
Cat # 15909994
100 µL
Cat # 15795911
100 µL
Cat # 16198338
50 µg
Cat # 15785911
100 µL
Cat # 16865205
20 µL
Cat # 17161914
100 µL
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